Background & objectives: Skin cancer is the most prevalent type of cancers in the world. Childhood and adolescence are important times for preventing the skin cancer. The aim of this study was to survey the effect of educational intervention based on BASNEF model on preventive practices of skin cancer among female high school students in Mehresan.

Methods: This quasi-experimental study was conducted on 240 female students from four high schools in Mehrestan, Iran. Questionnaires containing constructions of BESNEF model were filled in before the intervention (pre-test) and two-months later for both case and control groups. T-test, ANOVA, Chi-square, paired t-test, and Pearson’s correlation coefficients were used to analyze the data using SPSS.

Results: Mean scores of BASNEF model constructs displayed significant differences between before and after education in control group (p<0.001). Enabling factors with an influence of 0.432 among the BASNEF model constructs was the strongest predictor of protection against the sun light.

Conclusion: The results of this study showed that educational program based on BASNEF model is effective on promoting preventive behaviors of skin cancer among students.