Background & Objectives: Menopausal period is one of the most critical stages of women’s lives. One of the aims of health for all in the 21st century is quality of life improvement. The quality of life changes significantly following menopausal status which is very important from the public health view. Due to importance of health promotion and improving women’s quality of life following menopausal, present study was conducted to assess quality of life among postmenopausal women in Kerman. Methods: This cross-sectional study was conducted on 384 healthy postmenopausal women aged 48-64 years in Kerman. Convenience sampling technique was applied. WHOQOL-BREF questionnaire, which was previously validated for Iran, was used to determine quality of life. Results: The results showed that overall quality of life was medium in %68 of the cases. The mean quality of life was 10.22±4.05 in physical¸ 9.48±3.7 in psychological, 4.33±2.02 in social¸ and 12.73±5.05in environmental domain. Conclusion: This study showed that menopause causes changes in the quality life of women so that most of women had medium quality of life at physical¸ psychological¸ social and environmental domains.Therefore, designing and implementing appropriate educational programs are necessary to promote the quality of life in menopausal women.