Background & Objectives: Amputation as a major challenge in medicine has been heart-breaking for the patients and their companies and imposes high cost for the society and health system. The aim of this study was to determine frequency of types and causes of organ amputation in Fatemi Hospital in 2010. Methods: This retrospective descriptive-analytical study was done on 153 individuals who hospitalized due to organ amputation in Fatemi Hospital. Information on different variables and types of amputations and their causes were collected and analyzed by statistical tests using SPSS.18 software. Results: 110 (72%) patients were male with the rest being female. The mean age of patients was 39.6 years and the age of about 50% of the cases ranged from 15 to 45 years. Literacy level of 75% of the patients was diploma and lower. Finger amputation (119 cases) was the most prevalent type of amputation (77.8%). Etiologically, trauma with 127 cases (83%) was the dominant cause of amputation. About 50% of the traumatic amputations were associated with occupational trauma that most of them occurred due to working with agricultural machineries. Conclusion: These results indicate high rate of trauma and low level of safety conditions in working environments in Ardabil province, which requires necessary measures to be taken in this field.