Background & Objective: General health can be affected by occupational factors. The purpose of this study was to investigate the role of general health in job satisfaction of the workers in Khalkhal chipboard factory. Methods: This cross-sectional and descriptive study was carried out in December 2013. The research environment was Khalkhal chipboard factory and the study population included 98 workers employed in different shifts of the factory. The data gathering instruments were General Health Questionnaire (GHQ-28) and standard questionnaire (JDI-55). Data analysis was done by calculating correlation coefficients and descriptive statistics indices using SPSS version 16. Results: There is a significant and positive correlation between job satisfaction and general health (p<0.00001). Job satisfaction displayed positive correlation with general health in the fields of workplace (p<0.0001), supervisor (p<0.006), colleagues (p<0.002), promotion opportunities (p=0.011), and workplace conditions (p=0.004) significant, while there was no correlation between general health and payments field (p=0.092). Conclusions: According to the relationships between general health and job satisfaction of the workers, the necessity of providing safety and workplace environment standards, timely and appropriate promotion opportunities, and improvement of workplace conditions are emphasized.