IgA نفروپاتی یکی از شایع ترین گلومرولونفریت های اولیه در سراسر جهان است که با رسوب کمپلکس های ایمنی حاوی IgA در مزانژیوم گلومرول مشخص می شود و آسیب پیشرونده و تدریجی کلیه ها را به همراه دارد. این بیماری تظاهرات بالینی متعددی مثل پروتئینوری و هماچوری و نارسایی کلیه دارد و سیر بیماری در افراد مبتلا به آن می تواند متغیر باشد؛ در نتیجه، چالش های متعددی در درمان این بیماری وجود دارد. با توجه به ناهمگونی بیماری، درمان های متعددی برای آن پیشنهاد شده که این درمان ها در حال تکامل هستند اما به نظر می رسد بهتر است رویکرد درمان به سمت درمان های شخصی سازی شده تغییر یابد و درمان بر اساس داده های ژنتیکی و بیومارکرها انجام شود. این مرور با هدف ارائه یک دیدگاه جامع از پیشرفتهای اخیر در درمان IgA نفروپاتی، با تمرکز ویژه بر درمانهای نوآورانه که در آزمایشات بالینی اخیر نتایج امیدوارکنندهای نشان دادهاند یا در حال حاضر تحت بررسی هستند، تهیه شده است. امید است با ادامه تحقیقات و نوآوری درمانی، پیشرفت های بیشتری در کنترل علائم و بهبود عملکرد کلیوی داشته باشیم.
نوع مطالعه: پژوهشي |
موضوع مقاله: عمومى دریافت: 1404/1/31 | پذیرش: 1403/10/12 | انتشار: 1403/10/12
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