Background & Objectives: Human errors and accidents, the most important factors influencing quantitative and qualitative indices of production, directly depend on safety programs. Safety programs show their effects on personnel as occupational satisfaction, workforce productivity, and occupational deceases and on the products as a production quality. Methods: This is a retrospective and descriptive–analytical study conducted based on five years recorded documents and statistics in Ilam province (Iran) food industries. Data were collected using checklists and questionnaires. The effectiveness of safety programs were determined using safety indices including risk assessment, audit, personnel safety training, and investment on personal protective equipments and accident degree were investigated applying indices including accident severity, accident frequency, accident frequency-severity, and occupational decease frequency for a period of 5 years. Results: Average accident and occupational disease indices were decreased after implementation of OHSAS 18001and HACCP programs (P<0.05(. Conclusion: The results have showed that implementation of safety programs has positive effect on accident indices in the form of reduction in accident severity, accident frequency, accident frequency-severity, and occupational decease frequency indices and subsequently improved organizational productivity.